A brilliant neurosurgeon finds his life in utter turmoil after getting involved with a psychopathic former patient.
Dr. Kenzo Tenma disobeys orders to operate on a wealthy donor, following his conscience to operate on a small boy named Johan instead.
Dr. Tenma saves Johan's life, but Mayor Roedecker dies during surgery under Dr. Boyer, prompting Dr. Oppenheim to send a report to the director.
Inspector Lunge suspects Dr. Tenma in the deaths of three doctors and the disappearance of the Liebert twins; however, he is eventually promoted.
Junkers is interrogated about the murders and Dr. Tenma persuades him to confess.
While Dr. Tenma investigates the serial murders of middle-aged, childless couples and Johan's true identity, law student Nina Fortner receives poetic emails.
With the help of Maurer, a local journalist, Dr. Tenma is able to track down the Fortners on the day of the twins' twentieth birthday.
Dr. Tenma and Nina arrive at a gruesome scene, finding the Fortners and a journalist dead. Anna's confession of shooting Johan brings back memories.
Dr. Tenma returns to work at a hospital in Dusseldorf but is forced to flee when the police suspect him of killing an elderly couple.
Dr. Tenma undergoes intense firearms training with a former army veteran named Hugo Bernhardt, who takes care of an orphaned girl.
While investigating the murder of a prominent councilman and his wife, Tenma encounters the petty criminal Otto Heckel and escapes with him.
Tenma learns that Johan used to be in an orphanage known as Kinderheim 511, where he meets an injured boy named Dieter and a former East German official named Hartmann who used to work there.
Dieter is picked up by Hartmann before Tenma could return, and Tenma learns more about the experiments in Kinderheim 511.
In a small village, Dr. Schumann worries over the health of his sick but stubborn old friend, Petra.
Workaholic Inspector Lunge is so focused on his job that he neglects his personal life. When a key suspect in his case commits suicide, he becomes obsessed with catching Tenma.
Tenma investigates the Heidelberg murders and learns of a right-wing nationalist organization that's planning to burn down the Turkish portion of Frankfurt. Nina is captured by the organization.
Nina finds Ayse dead at Baby's mansion, where Goedelitz and his men have been killed. Tenma is captured by General Wolf's men, but he sends Dieter to warn the Turkish community.
Tenma saves the Turkish community from a neo-Nazi fire plot, while Nina learns that Johan has a split personality.
Nina recalls her time working at an Italian restaurant and taking marksmanship lessons. She learns that her boss, Mr. Rosso, is a former assassin. She leaves to continue her search for Johan.
Tenma visits Dr. Gillen, a former rival, for help in understanding Johan. Dr. Gillen initially turns Tenma over to the authorities, but changes his mind after consulting with a prisoner who provides evidence of Johan's existence.
Tenma and Dieter hitch a ride with a former police officer and his wife.
Former detective Muller is lured into a trap by Johan, who has his bodyguard Roberto kill a private investigator and kidnap Nina.
Lunge sets a trap for Tenma, but is wounded by the real criminal.
Eva Heinemann is arrested for public drunkenness and is also homeless after not paying her rent.
Eva trades Johan's photos for Tenma's location.
In Munich, Karl Neumann and fellow student Lotte Frank engage in a series of events involving the elderly, blind, and wealthy Hans Georg Schuwald.
Schuwald hires a private investigator to look into Fahren's death, while Johan manipulates Karl into believing Schuwald is his father.
While Braun investigates Karl for Fahren's death, Johan manipulates Karl into reconciling with his real father, Schuwald.
Braun investigates Karl and Johan after becoming suspicious of their involvement in Fahren's death. His investigations lead him to believe that Johan is responsible for a series of murders aimed at isolating Schuwald.
Braun investigates Johan's origins and discovers that the real Johan Liebert died as a child.
Dr. Reichwein reflects on the suspicious death of his friend Richard Braun, leading Dr. Gillen to suspect foul play.
Dr. Reichwein hides Tenma in a safe house, but Tenma leaves to track down Johan.
Lotte has a chance encounter with Nina and discovers that they are both researching Schuwald.
Johan collapses after viewing a picture book.
Johan recovers from his fainting spell and responds to an invitation to visit the Red Hindenburg. Tenma visits a local doctor.
Lunge prioritizes his investigation over his personal life, questioning Tenma's former friends from Japan and discovering a crucial clue related to Johan's fainting spell.
Dr. Reichwein confronts Schuwald about Johan. Reichwein and Lunge both head to the library to stop Johan, while Lotte confronts Nina about her true identity.
Nina reads the picture book, "The Nameless Monster," triggering lost memories. She decides to confront Johan at the book donation ceremony.
The fire inside the library spreads, but people are trapped inside by locked doors.
Initially suspecting Tenma's involvement in the fire and the planned assassination of Schuwald, Lunge's perspective shifts when Karl asks him to search for Johan. Schuwald tasks Karl with delivering a message to someone in Dresden.
Wolfgang Grimmer, a freelance journalist and former East German, investigates child abuse and psychological reprogramming in former East Germany orphanages.
Grimmer investigates Petrov, who was present at the 511 Kinderheim revolt.
Grimmer is abducted and tortured by former Czechoslovakian StB members.
Detective Suk investigates the murders of his superior, two former StB members, and the commissioner, who were all poisoned.
The murder of Commissioner Hamrlik and the involvement of corrupt officers cause a media frenzy, while Suk investigates Petrov's orphanage.
The Czech police have turned their suspicions towards the journalist Grimmer and the young detective Suk for the murders of their former police chief and three former Czechoslovakian secret police members.
A Prague police detective from a special investigative team has been killed in Suk's room, and now Suk is being chased as a suspect in a series of murders. Tenma reads about the case in a newspaper.
Nina doesn't know that Johan has disguised himself as her and is confused when people in the street affectionately call her "Anna."
While searching for the sign with the three frogs, Nina is surprised that she knows the surrounding buildings and streets, but there is a shadow of fear in her memories.
All the orphans who adore Grimmer try to prove his innocence. They find the blonde woman (Johan, disguised as Anna) who was at the scene of the murder.
Inspector Lunge arrives at the Red Rose Mansion after finding a hint in a picture book. Afterwards, he meets with Captain Ranke, a leader of the former Czechoslovakian secret police.
In order to get close to the tycoon Schuwald, Johan used Schuwald's mistress, Margot Langer.
Tenma is caught in the Czech Republic. He is moved to a police department in Düsseldorf and is questioned daily.
After hearing Roberto's threat against Eva, Tenma decides to confess to all charges against him so he can be placed in the same van transporting a prisoner to a federal penitentiary as the prisoner is arranging for a jailbreak.
Tenma and Milch are on the run with the injured Gustav and Helene. Eva finds her life in danger when she discovers that the attorney she's supposed to meet, Mr.Baul, is none other than Roberto.
Tenma escapes with Milch and tries to warn Eva that she is in danger. Eva is staying in room 402 of the Hotel Steigent. Tenma is unable to contact Eva, so he heads to her room.
Tenma has escaped and is headed to his lawyer Verdemann's house. There, Tenma finds a message inviting him to the Red Rose Mansion. Tenma heads to the Czech Republic while decoding the encoded memo that Verdemann's father left behind.
Nina faints at the Red Rose Mansion and is saved by Lipsky, a puppeteer. When she recovers from the temporary shock, Nina remembers everything that happened on that tragic day when the Lieberts were killed.
Two months earlier, before Tenma escaped, Martin visited Eva's room and took her away. A mysterious man in Frankfurt told Martin to bring Eva to him.
While acting as Eva's bodyguard, Martin becomes determined to protect Eva, even from Tenma, who is searching for Eva.
Martin's attempt to save Eva costs him his life, his last minutes with Tenma reveal terrible secrets about Martin's boss, Peter Capek and about the experiments.
Nina returns to the apartment that she lived in and Johan and encounters another memory, Jan Suk and Fritz Verdemann team up to gather information on Franz Bonaparta.
Tenma is hit by a van while trying to escape from the police in Frankfurt. Upon trying to pursue Peter Capek, he awakes in the Turkish quarter of the city.
Inspector Weissbach, who was in charge of the murder cases concerning the Lieberts and the Eisler Memorial Hospital victims, is nearing retirement. His final job is to transport Dinger, a multiple homicide offender.
The Baby is a prominent right-wing extremist in Frankfurt. He became Capek's right-hand man with the aim of creating a new world order, but lately he's been distrustful of Capek's words and actions.
Nina has recovered all her memories and goes alone to Capek's villa in search of Johan. Meanwhile, acting on a note that Milan left behind, Tenma watches Christof, the young man who works with Capek.
Capek is at the mercy of a gun-toting Nina and leads her to Johan by car. On the way there, Capek reveals that Johan came just before Nina did, and that Johan told him to tell Nina where he was.
Johan, during his confrontation with Anna, reveals what he endured in the Red Rose Mansion as a child.
BKA inspector Lunge is standing on a hill that overlooks Ruhenheim, a peaceful country town. Lunge stays at a hotel whose only guests are an old married couple.
Inspector Lunge and Grimmer are standing on a hill that overlooks the town of Ruhenheim. A disaster will soon befall this seemingly peaceful town.
It continues to rain in the town of Ruhenheim. The phones don't connect, and it is completely isolated. Furthermore, gunshots can be heard throughout the town.
In the pouring rain, in the town of Ruhenheim, people have become suspicious of each other and have begun killing each other. Inspector Lunge is saving the surviving townspeople as he searches for the leader of the group that is inciting the massacre.
Inspector Lunge tracks down Roberto, the leader of the inciters, and charges in. But Inspector Lunge ends up being defeated by Roberto, who declares that he has no name.
Tenma is running through the town in the pouring rain with Franz Bonaparta, also known as Klaus Poppe, in order to save Inspector Lunge, who has gone off to arrest Roberto.
After the events in Ruhenheim, Tenma is cleared of the suspicion of multiple homicide, and the survivors of the case begin to move on with their lives.
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